• Four Job Mode: Optional extra challenge. Four jobs will be given to you at the start of the game; you will be unable to get any more. Furthermore, in order to leave the menu, you must have all four different jobs equipped to one party member each. This means you can switch which party member is in which job (Good for learning abilities from each other!), but you will still retain the same overall composition at all times. Abilities are not restricted; you can still freely equip any learned abilities, whether from the other jobs assigned or that have been found/purchased.
• Disallow ability placement: This is primarily designed for Four Job mode, but can be used with any setting. Abilities will not be placed in the game (in shops & rewards), but can be learned on jobs as per normal.
• Randomize Job Color Palettes: Completely cosmetic. Does exactly what it says on the tin.
• Place all rewards: Does what it says: all items, abilities, and magic will be obtainable somewhere. Note that due to Progressive Abilities's functionality, you may end up unable to collect them all.
• Enforce all jobs: Similar to placing all rewards; this covers Jobs explicitly and ensures they will all be discoverable somewhere in the game. Does nothing for you if Four Job Mode is also active.
• Progressive jobs: Strengthens bosses in Worlds 1 & 2 where their key item requirements are placed in Worlds 2 & 3. Explanation at the boss tiering page.

The biggest setting option currently available. This determines which worlds are available to you immediately, and the overall flow of your game:

• All Worlds Open: Easiest. Your WarpShard allows you to access all three worlds immediately, giving you full access to a huge number of shops and chests, as well as the convenience of many locations in the same world. All you need to do is get the 4 Tablets to enter the void and defeat NeoExdeath. Challenging Exdeath in his castle is entirely optional in this mode. If you do it, Tree Exdeath in the final battle will be reduced to 1 HP, and you will be given a choice of three non-tablet Key Items to take; these key items are duplicates, but may open up a good opportunity to you.
• Only World 1 available: Hardest. Your WarpShard can be used, but initially can only take you back to the default point in world 1, limiting your options for shops, chests, and bosses. Once you find the Adamantite key item, you can travel to World 2. Find the Bracelet and Anti-Barrier, and you can face Exdeath in his castle to unlock access to World 3. Finally, get all the tablets and you can take out Neo Exdeath.
• World 1 & 2 available: Middle ground. You will need to defeat Exdeath in his castle to access World 3, but are not locked out of world 2 shops/chests/boss locations at the start.

Refer to the randomization tiering page for an explanation on Reward Tiering, which is optional (default on).

Overflow Chance/Threshold is a chance that rewards from a given location will randomly be higher than stated. For instance, the default Chance of 10% and Threshold of 1 means that a World 2 shop has a 1/10 chance of carrying a tier 4 reward instead.

This changes the two drops (normal/rare) and two steals (normal/rare) for each enemy. None doesn't change drops/steals at all. Match only changes drops and steals for enemies that alreeady have them - empty slots remain empty. Full fills up the loot table of all enemies. Variable lets you set the chance that any given loot table slot is filled.

Randomizing the loot table in some manner is likely to be rewarding, as it's very rare for enemies or bosses to give much of value. However, there are some static drops that can be valued: Ramuh/Shoat/Golem by default drop their summons after being fought as a boss, for instance, and controlling Prototypes in World 1 is a popular source of Dark Matter for either Chemists or selling.

These settings yield much more chaotic results than the others, which tend to be more structured and sensible. They're all perfectly usable, but will have unpredictable consequences.

• Randomize Default Abilities: Every Job has 4 abilities when you switch to a Job, usually !Fight, !Item, and one other with a blank slot. This setting makes it such that every time you swap to a Job, you'll be getting 4 default abilities that are randomized. For instance, you could swap to Thief who has default abilities !X-Fight, !Dimen, !Flirt and !Mix. Given the nature of FFV, you can “unequip” the 3rd ability to something else (and the 2nd for Freelancer, and 2nd/4th for Mimic), but you can always re-apply the Job change to get those abilities back.
• Randomize Learning Abilities: Every Job has abilities it learns. This setting shuffles all learned abilities among all jobs. For example, a Knight in vanilla learns Cover → !Guard → 2Handed → EqShield → EqArmor → EqSword. With this setting, the Knight may learn !Summon3 → Learning → Preemptive → !X-Magic → !Jump → !MgcSwd6

This just affects default options in the Config menu of the game, so you don't have to adjust them manually. These options are still changeable in-game. They include the EXP/ABP multiplier and the menu colors.